![]() After the introduction of these guidelines, they were followed in most adult cases with vitiligo (71% of patients with localized vitiligo, 82% with generalized vitiligo, 100% with stable or segmental vitiligo, and 80% with universal vitiligo). Implementation of the guidelines was evaluated in 5 physicians. ![]() The final version of the guidelines consisted of a treatment scheme together with detailed treatment protocols. For vitiligo universalis, results of the systematic review showed that depigmentation using monobenzone or a Q-switched ruby laser was equally effective. From another systematic review, it could be concluded that patients with segmental, stable, or lip-tip vitiligo could be successfully treated with most autologous transplantation methods. The metaanalysis showed class 3 corticosteroids and narrowband UV-B to be the most effective and safest therapies for localized and for generalized vitiligo, respectively. Six months after the introduction of these guidelines, their use was evaluated.īefore the development of the guidelines, there was no uniformity in treatment selection, and there was a variability in estimates of treatment outcome. A final version of the guidelines was synthesized and disseminated among potential users. ![]() Scientific evidence obtained from 3 systematic reviews of the literature was combined with the results of 2 questionnaires and interviews of potential users of the guidelines, 3 internal expert meetings, and 1 local expert meeting, during which preliminary guidelines were presented and commented on. Patients, residents, and dermatologists from the Department of Dermatology, Academic Medical Center, University of Amsterdam, and the Netherlands Institute for Pigmentary Disorders in Amsterdam. To develop and introduce evidence-based guidelines for the treatment of vitiligo in children and in adults.
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